Mimosine Targets Serine Hydroxymethyltransferase
نویسندگان
چکیده
منابع مشابه
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication.
L-mimosine is a naturally occurring plant amino acid and iron chelator that arrests the cell cycle in the late G(1) phase, although its mechanism of action is not known. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting t...
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SHMT, EC 2.1.2.1, catalyzes the interconversion of Ser and Gly accompanied by the production or consumption of one-carbon units. In leaves it is a component of the photorespiratory pathway (Keys et al., 1978). The main function of that pathway is the salvage of reduced carbon and nitrogen withdrawn from the Calvin cycle by the oxygenation of ribulose 1,5-bisphosphate. By the cooFeration of SHMT...
متن کاملBacterial Threonine Aldolase and Serine Hydroxymethyltransferase Enzymes
for the enzyme in vivo unless an alkaline micro-environment was postulated or conditions were present in vivo which could potentiate inhibition by UMP at near-neutral pH (Yon, 19726). Substances such as deoxycholate which can bind to the hydrophobic site on the enzyme may provide such potentiation. Fig. 2 shows the effects of UMP and deoxycholate at pH values between 7 and 11. In the absence of...
متن کاملMosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut.
Lineage-specific microRNAs (miRNAs) may contribute to functions specific to hematophagous mosquitoes and, as such, have potential for contributing to the development of future mosquito control approaches. Here we report that the mosquito- and gut-specific miRNA, miR-1174, is required for proper sugar absorption, fluid excretion, blood intake, and, consequently, egg maturation and survival in fe...
متن کاملSerine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans.
The mel-32 gene in the free living soil nematode Caenorhabditis elegans encodes a serine hydroxymethyltransferase (SHMT) isoform. Seventeen ethylmethanesulfonate (EMS)-induced mutant alleles of mel-32(SHMT) have been generated, each of which causes a recessive maternal effect lethal phenotype. Animals homozygous for the SHMT mutations have no observable mutant phenotype, but their offspring dis...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.5.2548